Xin Chen, PhD

Beijing Medical University, Beijing China, Bachelor of Medicine, 1992, Medicine
Harvard University, Ph.D., 1997, Cell and Developmental Biology

• 1991-1992
  Undergraduate Research Assistant, Dept. of Biophysics, Beijing Medical University, Beijing, China
• 1992-1997
  Graduate Research Assistant, Dept. of Cell Biology, Harvard Medical School, Boston, MA
• 1997-1998
  Postdoctoral Research Fellow, Dept. of Cell Biology, Harvard Medical School, Boston, MA
• 1998-2001
  Postdoctoral Research Associate, Howard Hughes Medical Institute, Stanford University, Stanford, CA
• 2001-2002
  Research Associate, Dept. of Surgery, Stanford University, Stanford, CA
• 2003-present
  Assistant Professor, Dept. of Biopharmaceutical Science, UCSF, San Francisco, CA

• 1991-1992
  First Prize Award, Beijing Medical University, Beijing, China
• 1998-2001
  Postdoctoral Fellowship Award, Life Science Research Foundation, Baltimore, MD

• Chen X, Rubock MJ and Whitman M: "A transcriptional partner of MAD proteins in TGF-beta signaling" Nature, Vol. 383, Oct. 1996, pp691-696
• Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G and Whitman M: "Smad4 and FAST-1 in the assembly of activin response factor" Nature, Vol. 389, Sept. 1997, pp85-89
• Liu R, Liu H, Chen X, Martha K, Brown PO and Zhao K: "Regulation of CSF1 promoter by the SWI/SNF-like BAF complex" Cell, Vol. 106, Aug. 2001, pp309-318
• Chen X, Cheng ST, So SK, Fang ST, Barry C, Higgins J, Lai K, Ji J, Dudoit S, Ng I, vandeRijn M, Botstein D and Brown PO: "Gene expression patterns in human liver cancers" Molecular Biology of the Cell, Vol. 13, Jun. 2002, pp1929-1939
• Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, Ng IO, So SK and Fan ST: "Identification of metastasis-associated genes in hepatocellular carcinoma through delineation of the clonal relationship of the multi-nodular liver cancer" Cancer Research, Vol. 62, Aug. 2002, pp4711-4721
• Ji J*, Chen X*, Leung SY*, Chi J, Chu KM, Yuen SY, Li R, Chan A, Li J, Dunphy N and So S: "Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines" Oncogene, Vol. 21 (42), Sept. 2002, pp6549-6556
• Xu RH, Chen X, Chen DL, Li R, Addicks GC and Thomson JA: "BMP4 initiates human ES cell trophoblast differentiation" Nature Biotechnology, Vol. 20, Dec. 2002, p1261-1264
• Leung SY*, Chen X*, Chu KM, Yuen ST, Mathy J, Ji J, Chan A, Li R, Law S, Troyanskaya OG, Tu IP, Wong J, So S, Botstein D and Brown PO: "Phospholipase A2, Group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis" Proce Natl Acd Sci U S A, Vol. 99, Dec. 2002, pp16203-16208
• Chen X*, Leung SY*, Yuen ST, Chu KM, Ji J, Li R, Chan A, Law S, Troyanskaya OG, Wong J, So S, Botstein D and Brown PO: "Variation in gene expression patterns in human gastric cancers" Molecular Biology of the Cell, Vol. 14, Aug. 2003, pp3208-3215
• Sperger JM*, Chen X*, Draper JS, Antosiewicz JE, Chon C, Jones S, Brooks JD, Andrews PW, Brown PO and Thomson JA: "Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors" Proce Natl Acd Sci U S A, Vol. 100, Nov. 2003, pp13350-13355
• West RB, Corless CL, Chen X, Rubin B, Subramanian S, Montgomery K, Zhu S, Ball CA, Nielsen TO, Patel R, Boldblum JR, Heinrich MC, van de Rijn M: "The novel marker, DOG1, is expressed ubiquitously in GI Stromal tumors irrespective of KIT or PDGFRA mutation status" American Journal of Pathology, Vol. 165, July 2004, pp107-113
• Leung SY, Yuen ST, Chu KM, Mathy JA, Li R, Chan ASY, Law S, Wong J, Chen X and So S: "Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer" Gastroenterology, Vol 127(2), Aug. 2004, pp457-469
• Chen X, Higgins J, Cheung ST, Li R, Mason V, Montgomery K, Fan ST, van de Rijn M, and So S: "Novel endothelial cell markers in hepatocellular carcinoma" Modern Pathology, Vol 17(10), Oct. 2004, pp1198-1210
• Patil MA, Chua MS, Pan KH, Lin R, Lih CJ, Cheung ST, Ho C, Li R, Fan ST, Cohen SN, Chen X and So S: "An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma" Oncogene, Vol. 24(23), May 2005, pp3737-3747
• Furge KA, Dykema KJ, Ho C and Chen X: "Comparsion of array-based Comparative genomic hybridization with gene expression-based regional expression biases to identify genetic abnormalities in hepatocellular carcinoma" BMC Genomics, Vol. 6(1), May 2005: 67
• Patil MA, Gutgemann I, Zhang J, Ho C, Cheung ST, Gindinger D, Li R, Dykema KJ, So S, Fan ST, Kakar S, Furge KA, Buttner R and Chen X: "Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as potential target for 8q gain in hepatocellular carcinoma" Carcinogenesis, Vol. 26, Dec. 2005, pp2050-2057
• Giacomini C, Leung SY, Chen X, Yuen ST, KimY, Bair E, Tibshirani R, Pollack JR: "A legacy gene-expression signature of genetic instability in colon cancer" Cancer Research, Vol. 65, Oct. 2005, pp9200-9205
• Guo DL, Zhang J, Yuen ST, Tsui WY, Chan ASY, Ho C, Ji J, Leung SY and Chen X: "Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumors" Carcinogenesis, Vol. 27(3), Mar. 2006, pp454-464
• Wang YC, Juri D, Francisco B, Yu RX, Duran G, Chen K, Chen X and Sikic BI: "Regional activation of chromosome 7q with and without gene amplification in taxane-selected human ovarian carcinoma cell lines" Genes, Chromosomes and Cancer, Epub Dec. 2005
• Lamba JK, Chen X, Lan KB, Kim JW, Relling MV, Kazuto Y, Watkins PB, Strom S, Sun D, Schuetz JD and Schuetz EG: "Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans" Pharmacogenetics, Vol. 16(6), Jun, 2005, pp415-427
• Aggarwal A, Guo DL, Hoshida Y, Yuen ST, Chu KM, So S, Boussioutas A, Chen X, Bowtell D, Aburatani H, Leung SY and Tan P: "Topological and functional discovery in a gene co-expression meta-network of gastric cancer" Cancer Research, Vol. 66 (1), Jan. 2006, pp232-241
• Patil MA, Zhang J, Ho C, Cheung ST, Fan ST and Chen X: "Hedgehog signaling in human hepatocellular carcinoma" Cancer Biology and Therapy, Vol. 5(1), Jan. 2006, pp111-117
• Leung SY, Ho C, Tu IP, Li R, So S, Chu KM, Yuen ST and Chen X: "Comprehensive analysis of 19q12 amplification in human gastric cancers" Modern Pathology, Vol. 19(6), Jun. 2006, pp654-863
• Ho JC, Cheng ST, Patil MA, Chen X and Fan ST: "Increased expression of GPI anchor attachment protein (GPAA1) is associated with gene amplification in hepatocellular carcinoma" International Journal of Cancer, Vol. 119(6), Sept. 2006, pp1330-1337
• Zhang S, Lovejoy K, Shima JE, Lagpacan LL, Shu Y, Lapuk A, Gray JW, Chen X, Lippard SJ and Giacomini KM: "Organic cation transporters are determinants of oxaliplatin cytotoxicity" Cancer Research, Vol. 66(17), Sept., 2006, pp8847