Michelle Hermiston, MD, PhD

University of Iowa, B.S August, 1988, Physiology
Washington University School of Medicine, Ph.D., May, 1997, Developmental Biology
Washington University School of Medicine, M.D., May, 1997, Medicine
University of California, San Francisco, Resident, 1997-99, Pediatrics
University of Caliofrnia, San Francisco, Fellow, 1999-02, Hematology/Oncology

• 1988-1986
  Laboratory Technician/Phlebotomist, Universty of Iowa Hospital
• 1988-1989
  Research Assistant, University of Iowa, Laboratory of Robert E. Malone (Project: Isolation and characterization of genes involved in early events of meiotic recombination in S. Cervisiae.
• 1991
  Teaching Assistant, Anatomy, Washington University School of Medicine
• 1997-1999
  Resident, Department of Pediatrics, University of California, San Francisco
• 1999-2002
  Fellow, Pediatric Hematology/Oncology, University of California, San Francisco
• 2002-2004
  Adjunct Instructor, Pediatric Hematology/Oncology, University of California, San Francisco
• 2004-present
  Adjunct Assistant Professor, Pediatric Hematology/Oncology, University of California, San Francisco
• 2006-present
  Assistant Professor, Pediatric Hematology/Oncology, University of California, San Francisco

• 1987
  Mortar Board Honor Society, University of Iowa
• 1988
  Honors Graduate, University of Iowa
• 1988
  University of Iowa Homecoming Award for Excellence in Scholarship, Leadership, and Service
• 1990
  Medical Scientist Training Program Fellowship, Washington University
• 1990
  Edmond V. Cowdry Prize in Histology, Washington University
• 1993
  Spencer T. and Ann W. Olin Foundation Medical Scientist Fellowship, Washington University
• 1995
  Barbara Jackshik Award for Excellence in the Field of Cellular Regulation, Washington University
• 1996
  American College of Physicians Award for Excellence in Physical Diagnosis
• 1997
  American Medical Women's Association Janet M. Glasgow Memorial Achievement Citation, presented to women graduating in the top ten percent of their medical school class
• 1997
  Missouri State Medical Association Award for Outstanding Achievement in Medicine
• 1997
  Alpha Omega Alpha, Washington University School of Medicine
• 1997
  UCSF Molecular Medicine Research Fellowship Program
• 2001
  Molecular Oncology Investigator, University of California San Francisco Cancer Center
• 2004
  FASEB Summer Protein Phosphatase Research Conference Poster Award

• Refereed Manuscripts
• Malone, R.E., Bullard, S., Hermiston, M.L., Rieger, R., Cool, M., and Galbraith, A. Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics, 128:79-88 (1991).
• Roth, K.A., Hermiston, M.L., and Gordon, J.I. Use of transgenic mice to infer the biological properties of small intestinal stem cells and to examine the lineage relationships of their descendants. Proc. Natl. Acad. Sci. USA, 88:9407-9411 (1991)
• Hermiston, M.L., Latham, C.B., Gordon, J.I., and Roth, K.A. Simultaneous localization of six antigens in sections of transgenic mouse intestine using a combination of light and fluorescence microscopy. J. Histochem. Cytochem., 40:1283-1290 (1992)
• Hermiston, M.L., Green, R.P., and Gordon, J.I. Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated. Proc. Natl. Acad. Sci. USA, 90:8866-8870 (1993)
• Hermiston, M.L., and Gordon, J.I. In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J. Cell Biol., 129:489-506 (1995)
• Hermiston, M.L., and Gordon, J.I. Functional organization of the crypt-villus axis and evolution of its stem cell hierarchy during intestinal development. Amer. J. Physiol., 268 (Gastrointest. Liver Physiol. 31):G813-G822 (1995)
• Hermiston, M.L., and Gordon, J.I. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science, 270:1203-1207 (1995)
• Hermiston, M.L., Wong, M.H., and Gordon, J.I. Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for non-autonomous regulation of cell fate in a self-renewing system. Genes and Development, 10:985-996 (1996) (Cover photo)
• Wong, M.H., Hermiston, M.L., Snider, D., and Gordon, J.I. Forced expression of the tumor suppresser adeneomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium. Proc. Natl. Acad. Sci. USA, 93:9588-9593 (1996)
• Fazeli, A., Dickinson, S.L., Hermiston, M.L., Tighe, R., Steen, R.G., Small, C.G., Stoeckli, E.T., Keino-Masu, K., Masu, M., Rayburn, H., Simons, J., Bronson, R.T., Gordon, J.I., Tessier-Lavigne, M., and Weinberg, R.A. Phenotype of mice lacking Deleted in colorectal cancer (DCC) gene. Nature, 386:796-804 (1997)
• Hermiston, M.L., Tan, A., Gupta, V, Majeti, R., and Weiss, A. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity, 23:635-47 (2005)
• Hesslein, G.T.D., Takaki, R., Hermiston, M.L., Weiss, A., and Lanier, L.L. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc. Natl. Acad. Sci. USA 103:7012-17 (2006)
• Modica, R., Emergy, H., Lam, W., Hermiston, M., Grenert, J., Wirt, M., von Scheven, E. EBV associated B-cell lymphoproliferative disease in a child with NOMID. Arthritis Care & Research, in press.
• Hermiston, M.L., Tan, A.L., Cresalia, N., Abbas, A., and A. Weiss. The CD45 juxtamembrane wedge regulates T cell antigen receptor signaling during development and in mature T cell responses. Under revision.
• Chapters and Reviews
• Hermiston, M.L. and Gordon, J.I. Use of transgenic mice to characterize the multipotent intestinal stem cell and to analyze regulation of gene expression in various epithelial cell lineages as a function of their position along the cephalocaudal and crypt-to-villus (or crypt-to-surface epithelial cuff) axes of the gut. Seminars in Developmental Biology, 4:275-291 (1993)
• Hermiston, M.L., Simon, T.C., Crossman, M.W., and Gordon, J.I. Model systems for studying cell fate specification and differentiation in the gut epithelium: From worms to flies to mice. In "Physiology of the Gastrointestinal Tract, 3rd Ed." Johnson, L.R., Raven Press, New York, New York (1994)
• Gordon, J.I. and Hermiston, M.L. Differentiation and self-renewal in the mouse gastrointestinal epithelium. Current Opin. Cell Biol., 6:795-803 (1994)
• Hermiston, M.L., Xu, Z, Majeti, R, and Weiss, A. Reciprocal regulation of tyrosine phosphorylation by protein tyrosine kinases and protein tyrosine phosphatases. J. Clin. Invest., 109:9-14 (2002)
• Hermiston, M.L. and Mentzer, W.C. Approach to the Anemic Child. Pediatr. Clin. North Amer., 49:877-91 (2002)
• Xu, Z, Hermiston, M.L., and Weiss, A. CD45. In "Handbook for Cellular Signaling", Ed. Bradshaw, B. and Dennis, E., Elsevier, Atlanta, GA (2003)
• Hermiston, M.L., Xu, Z., and Weiss, A. CD45: A critical regulator of signal transduction thresholds in immune cells. Annual Review in Immunology, 21:107-137 (2003)