Scott C. Kogan, MD

Harvard College, Cambridge, MA, A.B., 1986, Biochemical Sciences
University of California San Francisco, M.D., 1991, Medicine
Laboratory Medicine Residency, UCSF, 1991-1993, Laboratory Medicine
Hematopathology Fellowship, UCSF, 1997-1998, Hematopathology

• 1984-1985
  Laboratory of Dr. David Calhoun, Mount Sinai Medical Center, New York City, NY.
• 1985-1986
  Laboratory of Dr. Leonard Guarente, Massachusetts Institute of Technology, Cambridge, MA.
• 1986-1991
  Laboratory of Dr. Jane Gitschier, Howard Hughes Medical Institute of California, UCSF
• 1991-1992
  Resident, Department of Laboratory Medicine, UCSF
• 1992-1993
  Chief Resident, Department of Laboratory Medicine, UCSF
• 1993-1997
  Laboratory of Dr. J. Michael Bishop, G.W. Hooper Foundation, UCSF
• 1997-1998
  Hematopathology Fellow, Department of Laboratory Medicine, UCSF
• 1998-2003
  Assistant Professor In-Residence, Department of Laboratory Medicine, UCSF
• 2003-2008
  Associate Professor In-Residence, Department of Laboratory Medicine, UCSF
• 2008-present
  Professor, Department of Laboratory Medicine, UCSF
• 2000-2004
  Chair, Hematopathology Subcommittee, Mouse Models of Human Cancer Consortium, NCI
• 2001-present
  Co-director, Mouse Pathology Shared Resource, UCSF Comprehensive Cancer Center
• 2004-2007
  Member Scientific Committee Clinical Laboratory Hematology, American Society of Hematology
• 2008-2009
  Chair Scientific Committee Hematopathology & Clinical Laboratory Hematology, ASH

• 1986
  Summa Cum Laude, Phi Beta Kappa
• 1986
  Joseph L. Barrett Award for Teaching, Harvard University
• 1993
  National Committee for Clinical Laboratory Standards, Honored Graduate Award
• 1993
  UCSF Molecular Medicine Training Program
• 1993
  American Cancer Society Physician Research Training Award
• 1994
  Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians
• 1997
  Burroughs Wellcome Fund Career Award
• 2000
  32nd Edward Mallinckrodt Jr. Scholar Award
• 2001
  Medical Student Teaching Award, Excellence for Small Group Instruction
• 2002
  Department of Laboratory Medicine Resident Teaching Award
• 2004
  Leukemia & Lymphoma Society Scholar Award
• 2007
  Mentor Award, UCSF Department of Pediatrics

• (Selected from 67 peer-reviewed publications)
• Brown, DE*; Kogan, SC*; Lagasse, E; Weissman, IL; Alcalay, M; Pelicci, P; Atwater, S; Bishop, JM. A PML-RARATransgene Initiates Murine Acute Promyelocytic Leukemia. Proc Natl Acad Sci USA 1997, 94:2551-2556. *These authors contributed equally to this work.
• Kogan, SC; Lagasse, E; Atwater, S; Bae, S; Weissman, I; Ito, Y, Bishop, JM. The PEBP2BMYH11 Fusion Created by Inv(16)(p13;q22) in Myeloid Leukemia Impairs Neutrophil Maturation and Contributes to Granulocytic Dysplasia. Proc Natl Acad Sci USA 1998, 95:11863-11868.
• Kogan, SC; Hong, SH; Shultz, DB; Privalsky, ML; Bishop, JM. Leukemia Initiated by PMLRAR: the PML Domain Plays a Critical Role while Retinoic Acid Mediated Transactivation is Dispensable. Blood (Plenary Paper) 2000, 95:1541-1550.
• Kogan, SC; Ward, JM; Anver, MR; Berman, JJ; Brayton, C; Cardiff, RD; Carter, JS; de Coronado, S; Downing, JR; Fredrickson, TN; Haines, DC; Harris, AW; Harris, NL; Hiai, H; Jaffe, ES; MacLennan, ICM; Pandolfi, PP; Pattengale, PK; Perkins, AS; Simpson, RM; Tuttle, MS; Wong, JF; Morse, HC III. Bethesda Proposals for Classification of Non-Lymphoid Hematopoietic Neoplasms in Mice. Blood 2002, 100:238-245
• Morse, HC III; Anver, MR; Fredrickson, TN; Haines, DC; Harris, AW; Harris, NL; Jaffe, ES; Kogan, SC; MacLennan, ICM; Pattengale, PK; Ward, JW. Bethesda Proposals for the Classification of Lymphoid Neoplasms in Mice. Blood, 2002, 100:246-258.
• Truong, BH; Lee, YJ; Lodie, TA; Park, DJ; Perrotti, D; Watanabe, N; Koeffler, HP; Nakajima, H; Tenen, DG; Kogan, SC. CCAAT/Enhancer Binding Proteins Repress the Leukemic Phenotype of Acute Myeloid Leukemia. Blood, 2003, 101:1141-1148.
• Sohal, J; Phan, VT; Chan, PV; Davis, EM; Patel, B; Kelly, LM; Abrams, T; O'Farrell, AM; Gilliland, DG; LeBeau, MM; Kogan, SC. A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657. Blood, 2003, 101: 3188-3197.
• Phan, VT; Shultz, DB; Truong, BH; Blake, TJ; Brown, AL; Gonda, TJ; Le Beau, MM; Kogan, SC. Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-RAR blocks growth factor mediated differentiation. Mol Cell Biol, 2003, 23: 4573-4585.
• Le Beau, MM; Davis, EM; Patel, B; Phan, VT; Sohal, J; Kogan, SC. Recurring Chromosomal Abnormalities in Leukemia in PML-RARA Transgenic Mice Identify Cooperating Events and Genetic Pathways to Acute Promyelocytic Leukemia. Blood, 2003, 102:1072-1074.
• Wendel, HG; de Stanchina, E; Fridman, JS; Malina, A; Ray, S; Kogan, S; Cordon-Cardo, C; Pelletier, J; Lowe, SW. Survival Signaling by AKT and eIF4E in oncogenesis and cancer therapy. Nature, 2004, 428:332-337.
• Fischbach, NA; Rozenfeld, S; Shen, W; Fong, S; Chrobak, D; Ginzinger, D; Kogan, SC; Radhakrishnan, A; Le Beau, MM; Largman, C; Lawrence, HJ. HOXB6 Over-expression in Murine Bone Marrow Immortalizes a MyelomonocyticPrecursor in vitro and Causes Hematopoietic Stem Cell Expansion and Acute Myeloid Leukemia in vivo. Blood, 2005, 105:1456-1466.
• Wang, J; Iwasaki, H; Krivtsov, A; Febbo, PG; Thorner, AR; Ernst, P; Anastasiadou, E; Kutok, JL; Kogan, SC; Zinkel, SS; Fisher, JK; Hess, JL; Golub, TR; Armstrong, SA; Akashi, K; Korsmeyer, SJ. Conditional MLL-CBP Targets GMP and Models Therapy-Related Myeloproliferative Disease. EMBO J. 2005, 24:368-381.
• Chao, RC; Pyzel, U; Fridlyand, J; Kuo, YM; Teel, L; Haaga, J; Borowsky, A; Horvai, A; Kogan, SC; Bonifas, J; Huey, B; Jacks, TE; Albertson, DG; Shannon, KM. Therapy-induced malignant neoplasms in Nf1 mutant mice. Cancer Cell, 2005, 8:337-348.
• Kuo, YH; Landrette, SF; Heilman, SA; Perrat, PN; Garrett, L; Liu, PP; Le Beau, MM; Kogan, SC; Castilla, LH. Cbf-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell, 2006, 9:57-68.
• Sternsdorf, T; Phan, V; Maunakea, ML; Ocampo, C; Sohal, J; Silletto, A; Galimi, F; LeBeau, MM; Evans, RM; Kogan, SC. Forced Retinoic Acid Receptor alpha Homodimers Prime Mice for APL-like Leukemia. Cancer Cell, 2006, 9:81-94.
• Wendel, HG; de Stanchina, E; Cepero, E; Ray, S; Fridman, JS; Emig, M; Veach, DR; Bornmann, WG; Clarkson, B; McCombie, WR; Kogan, SC; Hochhaus, A; Lowe, SW. Loss of p53 impedes the antileukemic response to BCR-ABL inhibition. Proc Natl Acad Sci USA, 2006, 103:7444-7449.
• Lee, YJ; Jones, LC; Timchenko, NA; Perrotti, D; Tenen, DG; Kogan SC. CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but they differ in their anti-leukemic activities. Blood, 2006, 108:2416-2419.
• Forsberg, C; Serwold, T; Kogan, S; Weissman, IL; Passegué, E. Megakaryocyte-Erythroid potential of hematopoietic stem and progenitocells: Fully multipotent Flk2/Flt3-positive early progenitors. Cell, 2006, 126:415-426.
• Wendel, HG; Malina, A; Zhao, Z; Zender, L; Kogan, SC; Cordon-Cardo, C; Pelletier, J; Lowe, SW. Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. Cancer Research, 2006, 66:7639-7646.
• Lee, BD; Sevcikova, S; Kogan, SC. Dual treatment with FLT3 inhibitor SU11657 and doxorubicin increases survival of leukemic mice. Leuk Res, 2007 31:1139-1142.
• Kim, A; Morgan, K; Hasz, DE; Wiesner, SM; Lauchle, JO; Geurts, JL; Diers, MD; Le, DT; Kogan, SC; Parada, LF; Shannon, K; Largaespada DA. Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice. Blood, 2007, 109:1687-1691.
• Joslin, JM; Fernald, AA; Tennant, TR; Davis, EM; Kogan, SC; Anastasi, J; Crispino, JD; Le Beau, MM. Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood, 2007, 110: 719-726.
• Mills, J; Hippo, Y; Robert, F; Chen, SM; Malina, A; Lin, CJ; Trojahn, U; Wendel, HG; Charest, A; Bronson, RT, Kogan, SC; Nadon, R; Housman, DE; Lowe, SW; Pelletier, J. mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci USA, 2008, 105:10853-10858.
• Viatour, P; Somervaille, TC; Venkatasubrahmanyam, S; Kogan, S; McLaughlin, ME; Weissman, IL; Butte, AJ; Passegué, E; Sage, J. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell, 2008, 3:416-428.
• Zuber, J; Radtke, I; Pardee, T; Zhao, Z; Rappaport AR; Luo, W; McCurrach, ME; Yang, M; Dolan, E; Kogan, SC; Downing, JR; Lowe, SW. Mouse models of human AML accurately predict chemotherapy response. Genes Dev, 2009, 23:877-889.
• Lauchle, JO; Kim, D; Le, DT; Akagi, K; Crone, M; Krisman, K; Warner, K; Bonifas, JM; Li, Q; Coakley, KM; Diaz-Flores, E; Gorman, M; Przybranowsk,i S; Tran, M; Kogan, SC; Roose, JP; Copeland, NG; Jenkins, NA; Parada, L; Wolff, L; Sebolt-Leopold, J; Shannon, K. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature, 2009, 461:411-414.
• Dail, M, Li, Q, McDaniel, A, Wong, J, Akagi, K; Huang, B; Kang, HC; Kogan, SC; Shokat, K; Wolff, L; Braun, BS; Shannon, K. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A, 2010, 107:5106-5111.
• Wong, JC; Zhang, Y; Lieuw, KH; Tran, MT; Forgo, E; Weinfurtner, K; Alzamora, P; Kogan, SC; Akagi, K; Wolff, L; Le Beau, MM; Killeen, N; Shannon K. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood, 2010, 115:4524-4532.
• Zhao, Z; Zuber, J; Diaz-Flores, E; Lintault, L; Kogan, SC; Shannon, K; Lowe, SW. p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev, 2010, 24:1389-1402.
• Subramanyam, D; Belair, C; Barry-Holson, K; Lin, H; Kogan, S; Passegué, E; Blelloch, R. PML-RAR and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res, 2010, 70:8792-8801.
• Jones, L; Wei, G; Sevcikova, S; Phan, V; Jain, S; Shieh, A; Wong, JCY; Li, M; Dubansky, J; Maunakea, ML; Ochao, R; Zhu, G; Tennant, TR; Shannon, KM; Lowe, S; Le Beau, M; Kogan, SC. Gain of MYC Underlies Recurrent Trisomy of the MYC Chromosome in Acute Promyelocytic Leukemia. J Exp Med, 2010, 22:2581-2594.
• Nakamura, JL; Phong, C; Pinarbasi, E; Kogan, SC; Vandenberg, S; Horvai, AE; Faddegon, BA; Fiedler, D; Shokat, K; Houseman, B; Chao, R; Pieper, RO; Shannon, K. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res, 2011 71:106-115.
• Li, Q; Haigis, KM; McDaniel, A; Harding-Theobald, E; Kogan, SC; Akagi, K; Wong, JC; Braun BS; Wolff L; Jacks T; Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011, 117:2022-2032.
• Premsrirut, PK; Dow LE; Kim, SY; Camiolo, M; Malone, CD; Miething, C; Scuoppo, C; Zuber, J; Dickins, RA; Kogan, SC; Shroyer, KR; Sordella, R; Hannon, GJ; Lowe SW. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell, 2011, 145:145-158.