Averil Ma, MD

Harvard University, Cambridge, MA, BA, 1980, Biochemistry
Columbia Medical School, New York, NY, MD, 1984, Medicine
Massachusetts General Hospital, Boston, MA, Internal medicine resident, 1987
Columbia Presbyterian Medical Center, New York, NY, Gastroenterology, 1990
Children’s Hospital, Immune Disease Institute, Boston, MA, Research Fellow/Instructor, 1996

• 1997-2003
  Assistant/Associate Professor, Medicine, Ben May Institute, University of Chicago, Chicago, IL
• 2004-2006
  Associate Professor of Medicine, UCSF, San Francisco, CA
• 2004-present
  Director, UCSF Colitis and Crohn’s Disease Center, Program in Biomedical Sciences (BMS), Program in Biological Sciences (PIBS), UCSF, San Francisco, CA
• 2006-present
  Rainin Distinguished Professor of Medicine
• 2009-present
  Institute of Molecular Medicine
• 2009-present
  MSTP Council
• 2008-present
  NIH CMI-A Study Section (2010-present, Chairman)
• 2011-present
  Chief, Division of Gastroenterology

• 1984
  Alpha Omega Alpha
• 1989
  James McDonnell Scholar in Molecular Oncology
• 1997
  Cancer Research Institute Scholar
• 2001
  American Society of Clinical Investigation
• 2001
  AGA/GRG Young Investigator Award
• 2009
  Elected Member, AAP

• (selected from a total of 70)
• Ma A, Smith R, Tesfaye A, Achacoso P, Dildrop R, Rosenberg N, and Alt FW. 1991. Mechanism of endogenous myc gene down-regulation in Eu-N-myc tumors. Mol Cell Biol 11;440-444.
• Ma A, Fisher PE, Oltz E, Dildrop R, Rathbun G, Achacoso P, Stall A, and Alt FW. 1992. Surface IgM mediated down-regulation of RAG gene expression in Eu-N-myc B cell lines. EMBO 11;2727-2734.
• Ma A, Moroy T, Collum R, Weintraub H, Alt FW, and Blackwell TK. 1993. DNA binding of N and L-myc proteins. Oncogene 8;1093-1098.
• Ma A, Pena J, Chang B, Margosian E, Davidson L, Alt FW, and Thompson CB. 1995. Bcl-x regulates the survival of double positive thymocytes. PNAS USA 92;4763-67.
• Ma A, Datta M, Margosian E, Chen J and Horak I. 1995. T cells, but not B cells are required for bowel inflammation in IL-2 deficient mice. J Exp Med 182;1567-1572.
• Lodolce JP, Boone DL, Dassopoulos T, Chai S, Swain RE, Trettin S, and Ma A. 1998. Interleukin-15R maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9;669-676.
• Ma, A, Boone, DL, and Lodolce, JP. 2000. Pleiotropic functions of IL-15: Not so IL-2 like after all. J Exp Med 191;753-755.
• Lee EG, Boone DL, Chai S, Libby S, Chien M, Lodolce JP, and Ma A. 2000. Failure to regulate TNF induced NF-B and cell death responses in A20 deficient mice. Science 289;2350-54.
• Lodolce JP, Burkett P, Boone DL, Chien M, Chai S, and Ma A. 2001. T cell independent IL-15R signals are required for bystander T cell responses. J Exp Med 194;1187-94.
• Boone DL and Ma A. 2002. Connecting the dots from Toll-like receptors to innate immune cells and inflammatory bowel disease. J Clin Inv 111;1284-1286.
• O'Shea JJ, Ma A, and Lipsky P. 2002. Cytokines and autoimmunity. Nat Rev Immunol 2;37-45.
• Schluns KS, Williams K, Ma A, Zheng XX, and LeFrancois L. 2002. Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol (Cutting Edge) 168;4827-31.
• Becker TC, Wheery J, Boone DL, Kaja-Krishna M, Antia R, Ma A, and Ahmed R. 2002. Role of IL-15 receptor alpha signals in immune responses to LCMV. J Exp Med 195;1541-48.
• Koka R, Burkett P, Boone DL, Lodolce JP, Chien M, Chan F, and Ma A. 2003. IL-15R deficient NK cells survive in normal but not IL-15R deficient mice. J Exp Med 197;977-984.
• Burkett P, Koka R, Chien M, Chai S, Chan F, Ma A, and Boone DL. 2003. IL-15R expression on CD8+ T cells is dispensable for T cell memory. PNAS USA 100;4724-4729.
• Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. 2004. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430;694-699.
• Koka R, Burkett P, Chien M, Chai S, and Ma A. 2004. Cutting Edge: Murine dendritic cells require IL-15R to prime NK cells. J Immunol (Cutting Edge)173;3594-3598.
• Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, McNally E, Pickart C, and Ma A. 2004. The ubiquitin modifiying enzyme A20 is essential for terminating TLR signaling. Nat Immunol 5;1052-60.
• Burkett PR, Koka R, Chien M, Chai S, and Ma A. 2004. Coordinate expression and trans presentation of IL-15R and IL-15 supports NK cell and memory CD8+ T cell homeostasis. J Exp Med 200;825-834.
• Ma A, Koka R, and Burkett PR. 2006. Diverse functions of IL-2, IL-7 and IL-15 in lymphoid homeostasis. Ann Rev Immunol 24:657-79.
• Ma A and Turer EE. 2006. E2 enzymes expand the Ubi-verse of immune receptor signaling. Nat Immunol 7;903-904.
• Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, and Abbott DW. 2007. IKKb phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NFkB pathway. Mol Cell Bio 27;7451-7461.
• Ma A. 2007. T-bet sends host-microbe mutualism awry. Cell 131;33-35.
• Turer EE, Tavares R, Hitotsumatsu O, Advincula R, Lee BL, Shifrin N, Malynn BA, and Ma A. 2008. Homeostatic MyD88 dependent signals cause lethal inflammation in the absence of A20 J Exp Med 205;451-464.
• Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shifrin N, Advincula R, Malynn BA, Werts C, and Ma A. 2008. The ubiquitin editing enzyme A20 restricts NOD2 triggered signals. Immunity 28;381-390.
• Mortier E, Woo T, Advincula R, Gozalo S, and Ma A. 2008. IL-15R chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans-presentation. J Exp Med 205;1213-1225.
• Werner SL, Kearns JD, Zadorozhnaya V, Lynch C, O'Dea E, Boldin MP, Ma A, Baltimore D, and Hoffman A. Encoding NFkB temporal control in response to TNF: distinct roles for the negative regulators IkBa and A20. 2008. Genes Dev 22;2093-2101.
• Musone SL, Taylor KE, Lu TT, Nititham J, Ferreira RC, Ortmann W, Shifrin N, Petri MA, Kamboh MI, Manzi S, Seldin MF, Gregersen PK, Behrens TW, Ma A, Kwok PY and Criswell LA. 2008. Multiple polymorphisms in the TNFAIP3 [A20] region are independently associated with systemic lupus erythematosus. Nat Genetics 40;1062-1064.
• Ma A. 2008. Unresolved ER stress inflames the intestine. Cell 134;724-726.
• Oshima S, Turer EE, Callahan JA, Advincula R, Chai S, Barrera J, Shifrin N, Lee B, Woo T, Yen B, Malynn BA, and Ma A. 2009. ABIN-1 is a ubiquitin sensor that restricts TNF induced cell death and sustains embryonic development. Nature 457;906-910.
• Malynn BA and Ma A. 2009. A20 takes on tumors: tumor suppression by a ubiquitin editing enzyme. J Exp Med 206;977-980.
• Sun JC, Ma A, and Lanier L. 2009. Cutting Edge: IL-15 Independent NK cell response to mouse cytomegalovirus infection. J Immunol (Cutting Edge) 183;2911-4.
• Mortier E, Advincula R, Kim L, Chmura S, Barrera J, Reizis B, Malynn BA, and Ma A. 2009. Macrophage and dendritic cell derived IL-15Ra support distinct CD8+ T cell subsets. Immunity 31;811-822.
• Ashida H, Kim M, Schmidt-Supprian M, Ma A, Ogawa M, and Sasakawa C. A bacterial E3 ubiquitin ligase IpaH9.8 effector targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response. Nat Cell Biol 12;66-73.
• Shembade N, Ma A, and Harhaj E. 2010. Inhibition of NF-{kappa}B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes. Science 327;1135-39.
• Tavares RM, Turer EE, Liu C-L, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, and Ma A. 2010. The Ubiquitin Modifying Enzyme A20 Restricts B cell Survival and Prevents Autoimmunity. Immunity 33;181-191.
• Malynn BA and Ma A. 2010. Ubiquitin makes its mark on immune regulation. Immunity 33;843-52.
• Skaug B, Chen J, Du F, He J, Ma A, and Chen ZJ. 2011. Direct, noncatalytic mechanism of IKK inhibition by A20. Molecular Cell 44;1-13.
• Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, Franco A, Criswell LA, Nakamura MC, and Ma A. 2011. Dendritic cell expression of A20 preserves immune homeostasis and prevents colitis and spondyloarthritis. Nature Immunology 12;1184-93.