David O. Morgan, PhD

University of Calgary, Canada, B.Sc. (Hon.), 1980, Animal Biology
University of California San Francisco, Ph.D., 1986, Endocrinology
University of California San Francisco, Post-Doc, 1986-1989, Biochemistry

• 1981-1986
  Ph.D. student in Endocrinology, Department of Physiology, UCSF, with Richard A. Roth
• 1986-1987
  Postdoctoral fellow with William J. Rutter, Department of Biochemistry & Biophysics, UCSF
• 1987-1989
  Postdoctoral fellow with Harold E. Varmus, Department of Microbiology & Immunology, UCSF
• 1989-1995
  Assistant Professor, Department of Physiology, UCSF. Joint appointment in Department of Biochemistry and Biophysics as of July, 1991
• 1995-1997
  Associate Professor, Departments of Physiology and Biochemistry & Biophysics, UCSF
• 1997-present
  Professor, Departments of Physiology and Biochemistry & Biophysics, UCSF
• 7/98-present
  Vice-chair, Dept. of Physiology, UCSF

• 1987-1989
  Helen Hay Whitney Foundation Postdoctoral Fellowship
• 1990-1993
  Searle Scholar Award
• 1990-1992
  March of Dimes Basil O'Connor Starter Scholar Award
• 1991-1996
  Rita Allen Foundation Scholar Award

• De Bondt, H.L., Rosenblatt, J., Jancarik, J., Jones, H.D., Morgan, D.O., and Kim, S.-H. (1993) Crystal structure of cyclin-dependent kinase 2. Nature 363, 595-602.
• Gu, Y., Turck, C.W., and Morgan, D.O. (1993) Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366, 707-710.
• Fisher, R.P., and Morgan, D.O. (1994) A novel cyclin associates with MO15/CDK7 to form the CDK activating kinase. Cell 78, 713-724.
• Shiekhattar, R., Mermelstein, F., Fisher, R.P., Drapkin, R., Dynlacht, B., Wessling, H.C., Morgan, D.O., and Reinberg, D. (1995) Cdk-activating kinase (CAK) complex is a component of human transcription factor IIH. Nature 374, 283-287.
• Fisher, R.P., Jin, P., Chamberlin, H.M., and Morgan, D.O. (1995) Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell 83, 47-57.
• Espinoza, F.H., Farrell, A., Erdjument-Bromage, H., Tempst, P., and Morgan, D.O. (1996) A major cyclin-dependent-kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science 273, 1714-1717.
• Kim, K.-K., Chamberlin, H.M., Morgan, D.O., and Kim, S.-H. (1996) Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. Nature Structural Biology 3, 849-855.
• Jin, P., Hardy, S., and Morgan, D.O. (1998) Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J. Cell Biol. 141, 875-885.
• Jaspersen, S.L., Charles, J.F., Tinker-Kulberg, R.L., and Morgan, D.O. (1998) A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9, 2803-2817.
• Jaspersen, S.L., Charles, J.F., and Morgan, D.O. (1999) Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9, 227-236.
• Takizawa, C.G., Weis, K., and Morgan, D.O. (1999) Ran-independent nuclear import of cyclin B1-Cdc2 by importin-beta. Proc. Natl. Acad. Sci. USA 96, 7938-7943.
• Tinker-Kulberg, R., and Morgan, D.O. (1999) Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and following DNA damage. Genes Dev. 13, 1936-1949.
• Jaspersen, S.L., and Morgan, D.O. (2000) Cdc14 activates Cdc15 to promote mitotic exit in budding yeast. Curr. Biol. 10, 615-618.
• Bishop, A.C., Ubersax, J.A., Petsch, D.T., Matheos, D., Gray, N.S., Blethrow, J., Shimizu, E., Tsien, J.Z., Schultz, P.G., Rose, M.D., Wood, J.L., Morgan, D.O., and Shokat, K.M. (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401.
• Garrett, S., Barton, W.A., Knights, R., Jin, P., Morgan, D.O., and Fisher, R.P. (2001) Reciprocal activation by CDK2 and CDK7 is directed by substrate specificity determinants outside the T-loop. Mol. Cell Biol. 21, 88-99.
• Kraybill, B.C., Elkin, L.L., Blethrow, J.D., Morgan, D.O., and Shokat, K.M. (2002) Inhibitor scaffolds as new allele-specific kinase substrates. J. Amer. Chem. Soc. 124, 12118-12128.
• Carroll, C.W., and Morgan, D.O. (2002) The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat. Cell Biol. 4, 880-887.
• Ubersax, J.A., Woodbury, E.L., Quang, P.N., Paraz, M., Blethrow, J.D., Shah, K., Shokat, K.M., and Morgan, D.O. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature, 425, 859-864.
• Carroll, C.W., Enquist-Newman, M., and Morgan, D.O. (2005) The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr. Biol. 15, 11-18.
• Loog, M., and Morgan, D.O. (2005) Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434, 104-108. (Commentary: Nature 434, 34-35; and Nat. Rev. Mol. Cell Biol. 6, 280)
• Carroll, C.W., and Morgan, D.O. (2005) Enzymology of the Anaphase-Promoting Complex. Meth. Enzymol. 398, 219-230.
• Thornton, B.R., Ng, T.M., Matyskiela, M.E., Carroll, C.W., Morgan, D.O., and Toczyski, D.P. (2006) An architectural map of the anaphase-promoting complex. Genes Dev. 20, 449-460.
• Woodbury, E.L., and Morgan, D.O. (2007) Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat. Cell Biol. 9, 106-112.
• Holt, L.J., Hutti, J.E., Cantley, L.C., and Morgan, D.O. (2007) Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol. Cell 25, 689-702.
• Rodrigo-Brenni, M.C., and Morgan, D.O. (2007) Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell 130, 127-139.
• Goga, A., Tward, A., Morgan, D.O., and Bishop, J.M. (2007) Inhibition of Cdk1 as a potential therapy for tumors over-expressing MYC. Nature Medicine, 13, 820-827.
• Blethrow, J.D., Glavy, J.S., Morgan, D.O., and Shokat, K.M. (2008) Covalent capture of kinase-specific phosphopeptides reveals novel Cdk1-cyclin B substrates. Proc. Natl. Acad. Sci. USA 105, 1442-1447.
• Enquist-Newman, M., Sullivan, M., and Morgan, D.O. (2008) Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol. Cell 30, 437-446.
• Holt, L.J., Krutchinsky, A.N., and Morgan, D.O. (2008) Positive feedback sharpens the anaphase switch. Nature 454, 353-357.
• Benanti, J.A., Matyskiela, M.E., Morgan, D.O., and Toczyski, D.P. (2009) Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol. Cell 33, 581-590.
• Matyskiela, M.E., and Morgan, D.O. (2009) Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol. Cell 34, 68-80.
• Holt, L.J., Tuch, B.B., Villen, J., Johnson, A.D., Gygi, S.P., and Morgan, D.O. (2009) Global analysis of Cdk1 phosphorylation sites provides insights into evolution. Science 325, 1682-1686.
• Rodrigo-Brenni, M.C., Foster, S.A., and Morgan, D.O. (2010) Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol. Cell 39, 548-559.