Joel M. Palefsky, MD

Mc Gill University, Montreal, Canada, M.D.,C.M., 1980, Medicine
Royal Victoria Hospital, Montreal, Canada, F.R.C.P(C), 1984, Internal Medicine
Stanford University, Stanford, CA, D.A.B.I.M. (Infec Dis), 1989, Medical Microbiology/Infectious Disease

• 1980-1983
  Residency in Internal Medicine, Royal Victoria Hospital, Montreal, Canada
• 1983-1984
  Post-doctoral Fellow, Department of Microbiology and Immunology, McGill University, Montreal, Canada
• 1984-1984
  Chief Medical Resident, Royal Victoria Hospital, McGill University, Montreal, Canada
• 1985-1989
  Post-doctoral Fellow, Division of Infectious Diseases, Stanford University
• 1989-1995
  Assistant Professor, Departments of Laboratory Medicine and Stomatology
• 1990-present
  Director, UCSF Anal Neoplasia Clinic
• 1996-1998
  Chair, UCSF Biosafety Committee
• 1998-present
  Vice-Chair UCSF Biosafety Committee
• 1999-present
  Professor, Departments of Medicine, Laboratory Medicine and Stomatology
• 1998-present
  Program Director, UCSF General Clinical Research Center
• 2001-present
  Program Leader Doris Duke Charitable Foundation Clinical Research Fellowhsip Program
• 2002-2009
  Co-Chair, Cancer and Immunity Program, UCSF Helen Diller Family Comprehensive Cancer Center
• 2003-present
  Chair, NCI AIDS Malignancy Consortium HPV Working Group
• 2004-present
  Chair, Special Populations Working Group, American Society for Colposcopy & Cervical Pathology
• 2006-present
  Associate Dean for Clinical and Translational Research

• 1984-1988
  Medical Research Council of Canada Fellowship
• 1988-1990
  American Social Health Association Fellowship
• 2003-present
  American Society for Clinical Investigation
• 2005
  Award for Excellence in Small Group Teaching

• Palefsky JM, Holly EA, Ralston ML, Jay N. Prevalence and risk factors for human papillomavirus infection of the anal canal in HIV-positive and HIV-negative homosexual men. J Infec Dis 177:361-367, 1998.
• Palefsky JM, Holly EA, Ralston ML, Jay N, Berry JM, Darragh TM. High incidence of anal high-grade squamous intraepithelial lesions among HIV-positive and HIV-negative homosexual/bisexual men. AIDS 12: 495-503, 1998.
• Palefsky JM, Minkoff H, Kalish LA, Levine A, Sacks HS, Garcia P, Young M, Melnick S, Miotti P, Burk R. Cervicovaginal human papillomavirus infection in HIV-positive and high-risk HIV-negative women. J Natl Cancer Inst 91:226-236, 1999.
• Lagenaur L, Palefsky JM. Regulation of EBV promoters in oral epithelial cells and lymphocytes, J Virol 73: 6566-6572,1999.
• Goldie SJ, Kuntz, KM, Weinstein MC, Freedberg, KA, Welton ML, Palefsky JM. The clinical-effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men. JAMA 281:1822-1829, 1999.
• Palefsky JM, Holly EA, Ralston ML, Da Costa M, Greenblatt RM. Prevalence and risk factors for anal HPV infection in HIV-positive and high-risk HIV-negative women. J Infec Dis 183:383-391, 2001.
• Haga T, Sun-Hun Kim S-H, Jensen RH, Darragh T, Palefsky JM. Detection of genetic changes in anal intraepithelial neoplasia (AIN) of human immunodeficiency virus (HIV)-positive and HIV-negative men. J Acq Immune Defic Syndr 26:256-262, 2001.
• Moscicki AB, Hills N, Shiboski S, Powell K, Jay N, Hanson E, Miller S, Clayton L, Farhat S, Broering J, Darragh T, Palefsky J. Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females. JAMA 285:2995-3002,2001.
• Minkoff H, Ahdieh L, Massad LS, Anastos K, Watts DH, Melnick S, Muderspach L, Burk R, Palefsky J. The effect of highly active antiretroviral therapy on cervical cytologic changes associated with oncogenic HPV among HIV-infected women. AIDS 15:2157-64, 2001.
• Da Costa MM, Hogeboom CJ, Holly EA, Palefsky JM. Increased risk of high-grade anal neoplasia associated with an HPV 16 E6 sequence variant. J Infec Dis 185:1229-37, 2002.
• Strickler HD, Palefsky JM, Shah KV, Anastos K, Klein RS, Minkoff H, Duerr A, Massad LS, Celentano DD, Hall C, Fazzari M, Cu-Uvin S, Bacon M, Schuman P, Levine AM, Durante AJ, Gange S, Melnick S, Burk RD. Human papillomavirus type 16 and immune status in human immunodeficiency virus-seropositive women. J Natl Cancer Inst. 95:1062-71, 2003.
• Piketty C, Darragh TM, Da Costa M, Bruneval P, Heard I, Kazatchkine MD, Palefsky JM. High prevalence of anal human papillomavirus infection and anal cancer precursors among HIV-infected persons in the absence of anal intercourse. Ann Intern Med. 138:453-9, 2003.
• Sethi N, Palefsky JM. Treatment of human papillomavirus (HPV) type 16 infected cells using HSV 1-TK-mediated gene therapy transcriptionally regulated by the HPV E2 protein. Hum Gene Ther 14:45-57, 2003.
• Baumgarth N, Szubin R, Dolganov GM, Watnik MR, Greenspan D, Da Costa M, Palefsky JM, Jordan R, Roederer M, Greenspan JS. Highly tissue substructure-specific effects of human papilloma virus in mucosa of HIV-infected patients revealed by laser-dissection microscopy-assisted gene expression profiling. Am J Pathol.165: 707-18,2004.
• Sethi N, Palefsky J. Transcriptional profiling of dysplastic lesions in K14-HPV16 transgenic mice using laser microdissection. FASEB J 79:1099-112,2004.
• Chin-Hong PV, Vittinghoff E, Buchbinder S Cohen D, Colfax G, Da Costa M, Darragh T, Hess E, Judson F, Koblin B, Madison M, Palefsky JM. Age-related prevalence of anal human papillomavirus infection among sexually active men who have sex with men. J Infec Dis, 90:2070-6, 2004.
• Sharof Tugizov S, Berline J, Herrera R, Penaranda M-E, Nakagawa M, Palefsky JM. Inhibition of HPV16 E7 phosphorylation by the S100 MRP-8/14 protein complex. J Virol, 79: 1099-112, 2005.
• Chin-Hong PV, Vittinghoff E, Cranston RD, Browne L, Buchbinder S, Colfax G, Da Costa M, Darragh T, Jones Benet D, Judson F, Koblin B, Mayer KH, Palefsky JM. Age-related prevalence of anal cancer precursors In homosexual men: the EXPLORE study. J Natl Cancer Inst, 97:896-905, 2005
• Strickler HD, Burk RD, Fazzari M, Anastos K, Minkoff H, Massad LS, Levine AM, Watts H, Silverberg MJ, Xue X, Schlecht NF, Melnick S, Palefsky JM. Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst 97:577-86, 2005.
• Gagne SE, Jensen R, Polvi A Da Costa M, Ginzinger D, Efird JT Holly EA, Darragh T, Palefsky JM. High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia, J Acq Immun Defic Syndr 2005; 40: 182-9.
• Palefsky JM, Holly EA, Efird JT, Da Costa M, Jay N, Berry JM, Darragh TD (2005). Anal intraepithelial neoplasia in the HAART era among HIV-positive men who have sex with men. AIDS 19:1407-14.
• Frazer IH, Cox JT, Mayeaux EJ Jr, Franco EL, Moscicki AB, Palefsky JM, Ferris DG, Ferenczy AS, Villa LL. Advances in Prevention of Cervical Cancer and Other Human Papillomavirus-Related Diseases. Pediatr Infect Dis J. 2006 Feb;25(2 Suppl):S65-S81.
• McGhee EM, Cotter PD, Weier JF, Berline JW, Turner MA, Gormley M, Palefsky JM. Molecular cytogenetic characterization of human papillomavirus16-transformed foreskin keratinocyte cell line 16-MT, Genes, Chrom and Cancer, accepted for publication, 2006.
• Sroussi HY, Berline J, Palefsky JM, Oxidation of methionine 63 and 83 regulates the effect of S100A9 on the migration of neutrophils in vitro. J Leukoc Biol. [Epub ahead of print], 2006.
• Xiao J, Palefsky JM, Herrera R, Tugizov SM, Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Virology. [Epub ahead of print], 2006.