UCSF Helen Diller Family Comprehensive Cancer Center - People

ARTHUR WEISS, MD, PHD

Ephraim P. Engleman Distinguished Professorship, UCSF
Chief, Rheumatology Division, UCSF
Member, Biomedical Sciences Program (BMS), Herbert Boyer Program in Biological Sciences (PIBS), and Immunology Graduate Program, UCSF

CONTACT

aweiss@medicine.ucsf.edu
(415) 476-8983 (voice)
(415) 502-5081 (fax)

Box 0795, UCSF; San Francisco, CA 94143-0795

additional websites:

Research Profile

EDUCATION
University of Chicago, Chicago, IL, Ph.D., 1978, Immunology University of Chicago, Chicago, IL, M.D., 1979, Medicine
PROFESSIONAL EXPERIENCE
1979-1980	Postdoctoral Fellow, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
1980-1982	Resident, Department of Medicine, University of California San Francisco
1982-1984	Fellow in Rheumatology/Clinical Immunology, University of California San Francisco
1982-1985	Associate, Howard Hughes Medical Institute, San Francisco
1984-1985	Instructor, Department of Medicine, Division of Rheumatology/Clinical Immunology, University of California San Francisco
1985-1989	Assistant Investigator, Howard Hughes Medical Institute, San Francisco
1985-1989	Assistant Professor of Medicine, Microbiology and Immunology, University of California San Francisco
1987-present	Chief, Division of Rheumatology/Clinical Immunology, Department of Medicine, University of California San Francisco
1989-1993	Associate Investigator, Howard Hughes Medical Institute, San Francisco
1991-present	Ephraim P. Engleman Distinguished Professor of Rheumatology, University of California San Francisco
1992-present	Professor of Medicine, Microbiology and Immunology, University of California San Francisco
1993-present	Investigator, Howard Hughes Medical Institute, University of California San Francisco
1998-present	Associate Director, The Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco
2002-present	Director, Medical Scientist Training Program (MSTP) University of California, San Francisco
HONORS & AWARDS
1990	Young Investigator, Western Society for Clinical Investigation
1990	Henry Kunkel Young Investigator Award, American College of Rheumatology
1993	Junior Investigator Award, American Association of Immunologists
1997	Lee C. Howley Prize, Arthritis Foundation
1998	Forty-first Faculty Research Lecturer, University of California San Francisco
2001	American Association of Immunologist-Huang Foundation Meritorious Career Award
2003	Fellow, American Academy of Arts and Sciences
2004	Fellow, American Academy of Microbiology
2004	American College of Rheumatology Distinguished Investigator Award
2004	Distinguished Investigator Award, American College of Rheumatology
2004	Walter Bauer Visiting Professor in Rheumatology, Massachusetts General Hospital
2004	Bridget Ogilvie Lecture, University of Dundee, Scotland
2004	Sue Kim Hansen Lecture, Boston University School of Medicine
2005	Dan H. Campbell Memorial Lecture, Midwinter Conference of Immunologists, Asilomar, CA
2005	Visiting Professor, Harvard Medical School Rheumatology Division
2005	Beirne B. Carter Lecture in Immunology, University of Virginia
SELECTED PUBLICATIONS
(from 165 publications)
Lin, J, Weiss, A: The tyrosine phosphatase CD148 is excluded from the immunologic synapse and downregulates prolonged T cell signaling. J Cell Biol 2003; 162:673-682.
Tomlinson, MG, Kane, LP, Su, J, Kadlecek, TA, Mollenauer, MN, Weiss, A: Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Mol. Cell. Biol 2004; 24:2455-2466.
Andres, PG, Howland ,KC, Nirula A, Kane, LP, Barron, L, Dresnek D, Sadra, A, Imboden, J, Weiss A, Abass, AK: Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nature Immunol 2004; 5:435-4492.
Crotzer, VL, Mabardy,AS, Weiss, A, Brodsky FM: T cell receptor engagement leads to phosphorylation of Clathrin heavy chain during receptor internalization. J Exp Med 2004; 199:981-991.
Kane LP, Mollenauer MN, Weiss, A: A proline-rich motif in the C Terminus of Akt contributes to its localization in the immunological synapse. J Immunol 2004; 172:5441-5449.
Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss, A: Expression and function of Tec, Itk, and Btk in lymphocytes; Evidence for a unique role for Tec. Mol Cell Biol 2004; 24:2455-2466.
Lin J, Zhu JW, Baker JE, Weiss, A: Regulated expression of the receptor-like tyrosine phosphatase CD148 on hematopoietic cells. J Immunol 2004; 173:2324-2330.
Rassenti LZ, Huynh L, Toy TL, Chen L, Gribben JG, Keating MJ, Rai KR, Finn IW, Byrd JC, Kay NE, Greaves A, Weiss A, Kipps TJ. ZAP-70 compared with immunoglobulin heavy-chain mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N. Eng. J. Med 2004; 351:893-901.
Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A: SHIP family of inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. J. Biol. Chem 2004; 279:55089-55096.
Chen, L, Apgar, J, Huynh, L, Dicker, F, Giago-McGahan, T, Rassenti, L, Weiss,A, Kipps, TJ: ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood, 2005,105:2036-41.
Phee, H, Abraham, RT, Weiss, A: Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol. 2005, 6:608-17.
Roose, JP, Mollenauer, M, Gupta, VA, Stone, J, Weiss, A: A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol. 2005, 11:4426-41.
Brdicka, T, Kadlecek, TA, Roose, JP, Pastuszak, AW, Weiss, A: Intramolecular regulatory switch in ZAP- 70: analogy with receptor tyrosine kinases. Mol Cell Biol, 2005, 12:4924-33.
Myers, MD, Dragone, LL, Weiss, A: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation. J Cell Biol, 2005, 170:285-94.
Hermiston, ML, Tan, AL, Gupta, VA, Majeti, R, Weiss, A: The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity, 2005, 6:635-47.
Myers, MD, Sosinowski, T, Dragone, LL, White, C, Band, H, Gu, H, Weiss, A.: Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat Immunol. 2006, 1:57-66.
Dragone, LL, Myers, MD, White, C, Sosinowski, T, Weiss, A: Src-like adaptor protein regulates B cell development and function. J Immunol. 2006, 176:335-45.
Hesslein, D.G.T., Takaki, R., Hermiston, M.L., Weiss, A, Lanier, L.: Dysregulation of signaling pathways in CD-45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc Natl Acad Sci USA. 103:7012-7017, 2006.
Nirula, A, Ho, M, Phee, H, Roose, J, Weiss, A: Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J. Exp. Med. 203:435-442, 2006.
1/25/07

This site will look much better in a browser that supports web standards, but it is accessible to any browser or Internet device. Please upgrade your browser.